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1.
Int J Mol Sci ; 23(15)2022 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-35897785

RESUMO

Alzheimer's disease (AD) is a multifactorial pathology characterized by ß-amyloid (Aß) deposits, Tau hyperphosphorylation, neuroinflammatory response, and cognitive deficit. Changes in the bacterial gut microbiota (BGM) have been reported as a possible etiological factor of AD. We assessed in offspring (F1) 3xTg, the effect of BGM dysbiosisdysbiosis in mothers (F0) at gestation and F1 from lactation up to the age of 5 months on Aß and Tau levels in the hippocampus, as well as on spatial memory at the early symptomatic stage of AD. We found that BGM dysbiosisdysbiosis with antibiotics (Abx) treatment in F0 was vertically transferred to their F1 3xTg mice, as observed on postnatal day (PD) 30 and 150. On PD150, we observed a delay in spatial memory impairment and Aß deposits, but not in Tau and pTau protein in the hippocampus at the early symptomatic stage of AD. These effects are correlated with relative abundance of bacteria and alpha diversity, and are specific to bacterial consortia. Our results suggest that this specific BGM could reduce neuroinflammatory responses related to cerebral amyloidosis and cognitive deficit and activate metabolic pathways associated with the biosynthesis of triggering or protective molecules for AD.


Assuntos
Doença de Alzheimer , Microbioma Gastrointestinal , Doença de Alzheimer/metabolismo , Peptídeos beta-Amiloides/metabolismo , Animais , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Modelos Animais de Doenças , Disbiose/complicações , Disbiose/tratamento farmacológico , Feminino , Inflamação/complicações , Transtornos da Memória/complicações , Transtornos da Memória/etiologia , Camundongos , Camundongos Transgênicos , Proteínas tau/metabolismo
2.
Rev. ADM ; 79(3): 129-135, mayo-jun. 2022. tab
Artigo em Espanhol | LILACS | ID: biblio-1377955

RESUMO

El Sistema de Notificación de Eventos Adversos de la FDA (FAERS por sus siglas en inglés), ha informado sobre ciertas reacciones ad- versas a las vacunas que de forma poco común se presentan, siendo los síntomas neurológicos los más frecuentes, como mareos, dolor de cabeza, neuralgias, espasmos musculares, mialgias y parestesias. CoronaVac-Sinovac® es una vacuna de virus completo químicamente inactivo para COVID-19, creada a partir de células renales de mono verde africano que han sido inoculadas con la cepa SARS-CoV-2 CZ02. Noventa jóvenes estudiantes voluntarios entre 20 y 30 años recibieron el esquema de inmunización en dos dosis con 50 días de diferencia. En el presente estudio se observaron síntomas secundarios a la primera y segunda dosis, empleando un instrumento de recolección de informa- ción referente al estado de salud previo y posterior a la administración de la primera y segunda dosis, enfocado a los efectos secundarios. Los resultados manifestaron como las sintomatologías más frecuentes: insomnio, cansancio, dolor en articulaciones, somnolencia y dolor localizado en zona de punción, siendo esta última la más frecuente, también se observó una asociación estrecha con el sexo, la edad y el índice de masa corporal. Son necesarios estudios con mayor número de población observada para establecer resultados concluyentes (AU)


The FAERS, FDA Adverse Event Reporting System, has reported certain adverse reactions to vaccines that may occur uncommonly, with neurological symptoms being the most frequent of this group, manifesting as dizziness, pain headache, neuralgia, muscle spasms, myalgia, and paraesthesia. CoronaVac-Sinovac® is a chemically inactive whole virus vaccine for COVID-19, created from African green monkey kidney cells that have been inoculated with the SARS-CoV-2 CZ02 strain. 90 young volunteer students between 20 and 30 years old received the immunization schedule in two doses 50 days apart, in the present study the symptoms secondary to the first and second dose were observed, using an instrument for collecting information regarding the health status before and after the administration of the first and second dose of vaccination, focused on side effects. The results showed as the most frequent symptoms: Insomnia, tiredness, joint pain, drowsiness and localized pain in the puncture area, the latter being the most frequent, a close association was also observed with sex, age, and body mass index. Studies with a larger number of observed populations are necessary to establish conclusive results (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Estudantes de Odontologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Vacinas contra COVID-19/efeitos adversos , Coleta de Dados , Esquemas de Imunização , SARS-CoV-2 , México
3.
PLoS One ; 17(3): e0265263, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35312730

RESUMO

This work proposes a methodology for the design, development, optimisation, and evaluation of amorphous rosuvastatin calcium tablets (BCS class II drug). The main goal was to ensure rapid disintegration and high dissolution rate of the active ingredient, thus enhancing its bioavailability. The design started from a careful selection of excipients, which due to their characteristics and proportions within the formulation allowed the use of their properties such as fluidity or granulometric distribution. The formulation was characterised using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT-IR) and powder X-ray diffraction (PXRD) methods. The galenic SeDeM methodology was used to establish the profile of the active ingredient-excipient mixture and guarantee its suitability for producing tablets by the direct compression method. The results demonstrate that the amorphous rosuvastatin calcium tablets formulation developed made it possible to obtain cost-effective tablets by direct compression with optimal pharmacotechnical characteristics that showed a remarkable disintegration and dissolution rate. The manufactured tablets complied with the pharmacopoeia guidelines regarding content uniformity, tablet hardness, thickness, friability, in vitro disintegration time and dissolution profile.


Assuntos
Cálcio , Excipientes , Varredura Diferencial de Calorimetria , Excipientes/química , Rosuvastatina Cálcica , Solubilidade , Espectroscopia de Infravermelho com Transformada de Fourier , Comprimidos , Difração de Raios X
4.
San Salvador; s.n; 2022. 57 p.
Tese em Espanhol | BISSAL, LILACS | ID: biblio-1425827

RESUMO

La cetoacidosis diabética (CAD) es una de las principales complicaciones agudas de la Diabetes Mellitus (DM), además de ser una de las principales causas de morbimortalidad para pacientes que sufre de esta enfermedad. Es una complicación que se produce por una disminución en la insulina efectiva circulante, así como al aumento de hormonas contra-reguladoras, como glucagón, catecolaminas, cortisol y hormona de crecimiento (1). Por lo cual motiva a realizar la presente investigación con el fin de contribuir a los conocimientos de la población salvadoreña, para evitar las complicaciones agudas de la Diabetes Mellitus, y mejorar la calidad de vida de los pacientes que consultan, se tomara una población de 34 pacientes que ingresaron al Hospital Militar Central por Diabetes Mellitus, de los cuales 7 de ellos cumplían criterios clínicos y de laboratorio de Cetoacidosis Diabética en el periodo comprendido de enero a junio de 2022, se utilizó como técnica de investigación la consulta y revisión de expediente clinico virtual mediante un formulario de recolección de datos a partir del expediente clinico virtual del Sistema de Gestión Hospitalaria. Toda esta información recolectada se registró en una base de datos de Microsoft Excel para luego ser presentadas en tablas porcentuales y gráficos de barra. El Instrumento de recolección de datos incluye las características de la población estudiada las cuales eran pacientes cuyas edades iban desde los 18 hasta los 83 años de edad, de sexo masculino en su mayoría tratados con insulina y sulfonilureas, con estancia hospitalaria menor a los 7 días, los cuales como principal causa de Cetoacidosis diabética fue la inadecuada adherencia al tratamiento, además de presentar un cuadro resolutivo cuya duración fue menor a las 24 horas de estancia hospitalaria., así mismo se presentará formalmente al decanato de Medicina de la Universidad Salvadoreña "Alberto Masferrer" con el fin de que el presente documento contribuya a aportar conocimientos sobre la problemática en estudio.


Diabetic ketoacidosis (DKA) is one of the main acute complications of Diabetes Mellitus (DM), as well as being one of the main causes of morbidity and mortality for patients suffering from this disease. It is a complication that is produced by a decrease in effective circulating insulin, as well as an increase in counterregulatory hormones, such as glucagon, catecholamines, cortisol, and growth hormone (1). Therefore, it motivates to carry out the present investigation in order to contribute to the knowledge of the Salvadoran population, to avoid the acute complications of Diabetes Mellitus, and improve the quality of life of the patients who consult, a population of 34 will be taken. patients who were admitted to the Central Military Hospital due to Diabetes Mellitus, of which 7 of them met clinical and laboratory criteria for Diabetic Ketoacidosis in the period from January to June 2022, the consultation and review of clinical records was used as a research technique virtual through a data collection form from the virtual clinical record of the Hospital Management System. All this collected information was recorded in a Microsoft Excel database to later be presented in percentage tables and bar graphs. The data collection instrument includes the characteristics of the studied population, which were patients whose ages ranged from 18 to 83 years of age, mostly male, treated with insulin and sulfonylureas, with a hospital stay of less than 7 days. , which as the main cause of diabetic ketoacidosis was inadequate adherence to treatment, in addition to presenting a resolving picture whose duration was less than 24 hours of hospital stay, likewise it will be formally presented to the Dean of Medicine of the Salvadoran University "Alberto Masferrer" in order that this document contributes to provide knowledge about the problem under study.


Assuntos
Cetoacidose Diabética , Prevenção Primária , Diabetes Mellitus
5.
World J Gastroenterol ; 27(41): 7065-7079, 2021 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-34887628

RESUMO

Coronavirus disease 2019 (COVID-19) is a disease produced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is currently causing a catastrophic pandemic affecting humans worldwide. This disease has been lethal for approximately 3.12 million people around the world since January 2020. Globally, among the most affected countries, Mexico ranks third in deaths after the United States of America and Brazil. Although the high number of deceased people might also be explained by social aspects and lifestyle customs in Mexico, there is a relationship between this high proportion of deaths and comorbidities such as high blood pressure (HBP), type 2 diabetes, obesity, and metabolic syndrome. The official epidemiological figures reported by the Mexican government have indicated that 18.4% of the population suffers from HBP, close to 10.3% of adults suffer from type 2 diabetes, and approximately 36.1% of the population suffers from obesity. Disbalances in the gut microbiota (GM) have been associated with these diseases and with COVID-19 severity, presumably due to inflammatory dysfunction. Recent data about the association between GM dysbiosis and metabolic diseases could suggest that the high levels of susceptibility to SARS-CoV-2 infection and COVID-19 morbidity in the Mexican population are primarily due to the prevalence of type 2 diabetes, obesity, and metabolic syndrome.


Assuntos
COVID-19 , Diabetes Mellitus Tipo 2 , Microbioma Gastrointestinal , Adulto , Diabetes Mellitus Tipo 2/epidemiologia , Humanos , Obesidade/epidemiologia , SARS-CoV-2
6.
Int J Infect Dis ; 113: 225-232, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34628021

RESUMO

OBJECTIVES: COVID-19 is a viral transmissible disease and there is limited evidence on vertical transmission and prevalence of SARS-CoV-2 during pregnancy, birth, and the postnatal period. This descriptive cross-sectional study aimed to evaluate the possible perinatal transmission of SARS-CoV-2 in mothers and neonates in a Mexican population. METHODS: A total of 133 nasopharyngeal swab samples from mothers, 131 swab samples from neonates, and 140 colostrum samples were obtained, and the presence of SARS-CoV-2 was determined by qPCR. RESULTS: One in eight asymptomatic 38-39 weeks' pregnant women were positive for the presence of SARS-CoV-2 in nasopharyngeal swabs taken just before delivery; and one in 12 nasopharyngeal swabs collected from neonates immediately after delivery without breast feeding were also positive. It was also determined that one in 47 colostrum/milk samples were positive for the test. In addition, there was no association between positive results and any collected metadata of mothers or newborns. CONCLUSIONS: Asymptomatic women carried the SARS-CoV-2 virus during delivery, with perinatal transmission of SARS-CoV-2 to newborns. Since neonates were sampled immediately after birth, the detection of positive cases might be due to infection by the virus in utero.


Assuntos
COVID-19 , Complicações Infecciosas na Gravidez , Estudos Transversais , Feminino , Hospitais Públicos , Humanos , Recém-Nascido , Transmissão Vertical de Doenças Infecciosas , Gravidez , Complicações Infecciosas na Gravidez/epidemiologia , SARS-CoV-2
7.
Molecules ; 26(7)2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33916062

RESUMO

The objective of this study was to determine the oxidative stress and the physiological and antioxidant responses of coriander plants (Coriandrum sativum) grown for 58 days in soil with zinc oxide nanoparticles (ZnO NPs) and zinc sulfate (ZnSO4) at concentrations of 0, 100, 200, 300, and 400 mg of Zn/kg of soil. The results revealed that all Zn compounds increased the total chlorophyll content (CHLt) by at least 45%, compared to the control group; however, with 400 mg/kg of ZnSO4, chlorophyll accumulation decreased by 34.6%. Zn determination by induction-plasma-coupled atomic emission spectrometry (ICP-AES) showed that Zn absorption in roots and shoots occurred in plants exposed to ZnSO4 at all concentrations, which resulted in high levels of hydrogen peroxide (H2O2) and malondialdehyde (MDA). Only at 400 mg/kg of ZnSO4, a 78.6% decrease in the MDA levels was observed. According to the results, the ZnSO4 treatments were more effective than the ZnO NPs to increase the antioxidant activity of catalase (CAT), ascorbate peroxidase (APX), and peroxidases (POD). The results corroborate that phytotoxicity was higher in plants subjected to ZnSO4 compared to treatments with ZnO NPs, which suggests that the toxicity was due to Zn accumulation in the tissues by absorbing dissolved Zn++ ions.


Assuntos
Coriandrum/crescimento & desenvolvimento , Coriandrum/metabolismo , Peroxidação de Lipídeos , Nanopartículas Metálicas/química , Desenvolvimento Vegetal , Óxido de Zinco/química , Sulfato de Zinco/química , Antioxidantes/metabolismo , Biomarcadores , Coriandrum/efeitos dos fármacos , Peroxidação de Lipídeos/efeitos dos fármacos , Nanopartículas Metálicas/ultraestrutura , Oxirredução , Fotossíntese , Compostos Fitoquímicos/química , Desenvolvimento Vegetal/efeitos dos fármacos , Brotos de Planta/efeitos dos fármacos , Brotos de Planta/crescimento & desenvolvimento , Brotos de Planta/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Análise Espectral , Óxido de Zinco/metabolismo , Óxido de Zinco/farmacologia , Sulfato de Zinco/metabolismo , Sulfato de Zinco/farmacologia
8.
Behav Anal Pract ; 13(2): 421-433, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32642398

RESUMO

The teaching interaction procedure is an evidence-based procedure that has been utilized for the development of social skills. The teaching interaction procedure consists of labeling the targeted skill, providing a meaningful rationale for the importance of the skill, describing the steps of the targeted skill, modeling the skill, and providing feedback throughout the interaction. Although the teaching interaction procedure has been used to teach a variety of social skills to children and adolescents diagnosed with autism spectrum disorder (ASD) and other social and behavioral disorders, its use has not been evaluated for training staff. The purpose of this study was to evaluate the use of a teaching interaction procedure to teach 3 interventionists the skills to implement a teaching interaction procedure to target the development of social skills for children diagnosed with ASD. The results of a multiple-baseline design showed the teaching interaction procedure was effective at teaching all 3 interventionists how to implement a teaching interaction procedure.

9.
Rev. colomb. ciencias quim. farm ; 48(3): 528-546, sep.-dic. 2019. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1138769

RESUMO

SUMMARY The solubilities of celecoxib (CLX), a COX-2 selective nonsteroidal anti-inflammatory drug, were determined in water-ethanol and ethanol-ethyl acetate mixtures at several temperatures (288.15-308.15 K). The solubility curves as a function of ethanol ratio were studied at five temperatures, they showed a single maximum located at 50% ethanol-ethyl acetate (δ1 = 22.50 MPa1/2). The measurements of the variation of inherent drug solubility with temperature were used to estimate different thermodynamic parameters, enthalpy, entropy and Gibbs free energy of solution (ΔH S , ΔS S and ΔG S hm , respectively). The apparent enthalpies of the solution were a nonlinear function of the ethanol ratio in aqueous mixture. Non-linear enthalpy-entropy compensation analysis was observed indicating different dissolution mechanism with the variation in mixtures composition. The solubility enhancement is entropy driven at water-rich region (0-40% v/v ethanol) and enthalpy controlled at ethanol-rich region (40-100% v/v ethanol), likely due to water-structure loss around nonpolar moieties of the drug and for the ethanol-rich mixtures it is the enthalpy, probably due to the drug better solvation.


RESUMEN Se determinó la solubilidad del celecoxib (CLX), un fármaco antiinflamatorio no esteroide selectivo de COX-2, en agua-etanol y etanol-acetato de etilo a varias temperaturas (288,15-308,15 K). Los perfiles de solubilidad obtenidos fueron estudiados en función de la proporción de etanol en las cinco temperaturas de estudio. Los resultados muestran solamente un máximo en el 50% de etanol-acetato de etilo (δ1 = 22,50 MPa1/2). La variación de la solubilidad con la temperatura se utilizó para calcular diferentes parámetros termodinámicos, entalpia, entropía y energía de disolución libre de Gibbs (ΔH3, ΔS S y ΔGS hm, respectivamente). Las entalpias aparentes de disolución fueron no lineales en la mezcla acuosa. Además, se observó un análisis de compensación de entalpía-entropía no lineal, lo que indica un mecanismo de disolución que varía con la composición de cada mezcla. El aumento de la solubilidad es impulsado por la entropía en la región rica en agua (0-40% v/v de etanol) y la entalpía en la región rica en etanol (40-100% v/v de etanol), probablemente debido a la pérdida de la estructura del agua alrededor de los residuos no polares del fármaco y para las mezclas ricas en etanol es la entalpía, probablemente debido a la mejor solvatación del fármaco.

10.
Theor Biol Med Model ; 16(1): 4, 2019 02 26.
Artigo em Inglês | MEDLINE | ID: mdl-30803437

RESUMO

BACKGROUND: The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the feasibility of interrupting the parasite's life cycle in endemic areas. METHODS: A mathematical model that divides the population into susceptible, infected, and vaccinated individuals is formulated. The model is based upon the life cycle of the parasite. Computer numerical simulation experiments to evaluate the impact of pig vaccination under different vaccination schedules, and combined intervention strategies including pig vaccination and anthelmintic treatment against human taeniasis are carried out. RESULTS: Vaccination against either pig cysticercosis or against human taeniasis will influence the transmission dynamics not only among vaccinees but also the dynamics of the other hosts as well. When the protective efficacy and/or the coverage rate is less than 100%, different mass interventions like vaccinating the pig population twice in combination with chemotherapeutic treatment against human taeniasis, the elimination of the infection in both pigs and humans can also be achieved. CONCLUSIONS: Our mathematical model has the potential for planning, and designing effective intervention strategies including both mass vaccination and/or chemotherapeutic treatment to eliminate pig cysticercosis, human taeniasis and human neurocysticercosis. The model can be adapted to any given community with mild, moderate endemicity, or even in hyperendemic regions.


Assuntos
Cisticercose/prevenção & controle , Modelos Teóricos , Teníase/prevenção & controle , Vacinação/métodos , Vacinas/administração & dosagem , Animais , Cisticercose/transmissão , Tratamento Farmacológico/métodos , Humanos , Suínos , Teníase/transmissão
11.
Environ Earth Sci ; 78(20)2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31929835

RESUMO

This study evaluates factors affecting the spatial and temporal distribution of chlorinated volatile organic contaminants (CVOCs) in the highly productive aquifers of the karst region in northern Puerto Rico (KR-NPR). Historical records from 1982 to 2016 are analyzed using spatial and statistical methods to evaluate hydrogeological and anthropogenic factors affecting the presence and concentrations of multiple CVOCs in the KR-NPR. Results show extensive spatial and temporal distributions of CVOCs, as single entities and as mixtures. It is found that at least one type of CVOC is present above detection limits in 64% of the samples and 77% of the sampling sites during the study period. CVOC distribution in the KR-NPR is contaminant-dependent, with some species being strongly influenced by the source of contamination and hydrogeological characteristics of the system. Persistent presence of CVOCs in the KR-NPR system, even after contaminated sites have been subjected to active remediation, reflect the high capacity of the system to store and slowly release contaminants over long periods of time. This study shows that karst aquifers are highly vulnerable to contamination and can serve as a long-term route of contaminants to potential points of exposure.

12.
Theor Biol Med Model ; 15(1): 18, 2018 11 19.
Artigo em Inglês | MEDLINE | ID: mdl-30449280

RESUMO

BACKGROUND: Taenia solium is the aetiological agent of human taeniasis, pig cysticercosis and human neurocysticercosis, which are serious public health problems, especially in developing countries. METHODS: A mathematical model of the transmission dynamics of taeniasis-cysticercosis is formulated. The model consists of a coupled system of differential equations, which are density-dependent equations for describing the flow of the parasite through the life cycle. The model is hybrid since it comprises deterministic equations with stochastic elements which describe changes in the mean parasite burden and incorporates the overall pattern of the parasites' distribution. RESULTS: Sensitivity and bifurcation analyses were carried out to determine the range of values of the model. The model can reproduce the observed epidemiological patterns of human taeniasis, pig and human cysticercosis. For example, for a wide range of parameter values, the mean intensity of adult worms tends to rapidly stabilize in one parasite per individual host. From this model, we also derived a Susceptible-Infected model to describe the prevalence of infection in humans and pigs. Chemotherapeutic interventions against pig cysticercosis or human taeniasis may reduce rapidly and effectively the mean intensity of human taeniasis, pig cysticercosis and human cysticercosis. This effect can be achieved even if the protective efficacy of the drug is of the order of 90% and the coverage rate is 90%. This means that health in humans infected either with adult worms or cysticerci may be achieved by the application of anthelmintic drugs against pig cysticercosis. However, treatment against human cysticercosis alone, does not influence neither human teniasis nor pig cysticercosis. This is because human cysticercosis infection does not influence the value of the basic reproductive number (Ro). CONCLUSIONS: Even coverage of 100% in the administration of anthelmintics did not eliminate the infection. Then elimination of the infection in all hosts does not seem a feasible goal to achieve by administering only chemotherapeutic interventions. Throughout the manuscript a discussion of our model in the context of other models of taeniasis-cysticercosis is presented.


Assuntos
Anti-Helmínticos/uso terapêutico , Cisticercose/tratamento farmacológico , Cisticercose/transmissão , Modelos Teóricos , Taenia solium/efeitos dos fármacos , Animais , Anti-Helmínticos/farmacologia , Cisticercose/fisiopatologia , Humanos , Estágios do Ciclo de Vida/efeitos dos fármacos , Estágios do Ciclo de Vida/fisiologia , Suínos , Taenia solium/isolamento & purificação , Taenia solium/fisiologia , Teníase/tratamento farmacológico , Teníase/fisiopatologia , Teníase/transmissão
13.
Environ Pollut ; 237: 298-307, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29494923

RESUMO

This study investigates the occurrence of six phthalates and distribution of the three most-detected phthalates in the karst region of northern Puerto Rico (KRNPR) using data from historical records and current field measurements. Statistical data analyses, including ANOVA, Chi-Square, and logistic regression models are used to examine the major factors affecting the presence and concentrations of phthalates in the KRNPR. The most detected phthalates include DEHP, DBP, and DEP. At least one phthalate specie is detected above DL in 7% of the samples and 24% of the sampling sites. Concentrations of total phthalates average 5.08 ±â€¯1.37 µg L-1, and range from 0.093 to 58.4 µg L-1. The analysis shows extensive spatial and temporal presence of phthalates resulting from dispersed phthalate sources throughout the karst aquifers. Hydrogeological factors are significantly more important in predicting the presence and concentrations of phthalates in eogenetic karst aquifers than anthropogenic factors. Among the hydrogeological factors, time of detection and hydraulic conductivities larger than 300 m d-1 are the most influential factors. Persistent presence through time reflects continuous sources of phthalates entering the aquifers and a high capacity of the karst aquifers to store and slowly release contaminants for long periods of time. The influence of hydraulic conductivity reveals the importance of contaminant fate and transport mechanisms from contamination sources. This study improves the understanding of factors affecting the spatial variability and fate of phthalates in karst aquifers, and allows us to better predict their occurrence based on these factors.


Assuntos
Monitoramento Ambiental , Água Subterrânea/química , Ácidos Ftálicos/análise , Poluentes Químicos da Água/análise , Hidrologia
14.
J Autism Dev Disord ; 47(2): 243-259, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27807755

RESUMO

In this study we evaluated a social skills group which employed a progressive applied behavior analysis model for individuals diagnosed with autism spectrum disorder. A randomized control trial was utilized; eight participants were randomly assigned to a treatment group and seven participants were randomly assigned to a waitlist control group. The social skills group consisted of 32, 2 h sessions. Teachers implemented a variety of behaviorally based procedures. A blind evaluator measured participants' behavior immediately prior to intervention, immediately following intervention, and during 16 and 32-week maintenance probes. Results of the study demonstrated that participants made significant improvements with their social behavior (p < .001) following intervention, and the results were maintained up to 32 weeks after intervention had concluded.


Assuntos
Transtorno do Espectro Autista/psicologia , Transtorno do Espectro Autista/terapia , Terapia Comportamental , Psicoterapia de Grupo , Habilidades Sociais , Pré-Escolar , Feminino , Humanos , Masculino , Método Simples-Cego
15.
Notas enferm. (Córdoba) ; 16(27): 17-19, jul.2016.
Artigo em Espanhol | LILACS, BDENF - Enfermagem | ID: lil-789996

RESUMO

La mejora de la seguridad del paciente requiere de todo el sistema un esfuerzo complejo que abarque acciones dirigidas hacia la mejora del desempeño; la gestión de seguridad y los riesgos ambientales, incluidos el control de las infecciones, el uso seguro de los medicamentos, de los equipos, de la practica clinica y del entorno en el que se presta atencion sanitaria.Las precauciones de aislamiento crean barreras entre las personas y microbios. Estos tipos de precauciones ayudan a prevenir la propagacion de microbios en el hospital. Los diferentes tipos de precauciones de aislamiento protegen contra diferentes microbios. Acordar medidas para contribuir a la reducción de las infecciones asociadas a la atencion de salud (IAAS) y sus consecuencias es un objetivo primordial y un compromiso interdisciplinario. El presente trabajo desarrolla las medidas de aislamiento acordadas para desarrollar dentro de la institucion de salud...


Assuntos
Humanos , Isolamento de Pacientes , Controle de Infecções , Equipamento de Proteção Individual , Segurança do Paciente
16.
Notas enferm. (Córdoba) ; 15(26): 11-16, dez.2015.
Artigo em Espanhol | LILACS, BDENF - Enfermagem | ID: lil-776948

RESUMO

La terapia intravenosa (TIV)aporta múltiples beneficios en la atención de los pacientes, al tiempo pude asociar complicaciones, leves y localizadas como flebitis, en ocasiones pueden llegar a ser más graves o sistemáticas como el embolismo o sepsis. Del amplio abanico de complicaciones que se pueden presentar cuando se realiza TIV cabe destacar las relacionadas con la infección de mayor gravedad y las relacionadas a los accesos venosos centrales. El objetivo general fue analizar el estado de los accesos venosos periféricos y centrales de todos los pacientes internados en el Sanatorio Allende, sede Nueva Cordoba, entre los meses de abril-octubre de 2014. Metodologia: estudio descriptivo observacional de corte transversal.Se utilizó el diseño de patrullaje, la tabla de Score de Flebitis, para medir los hallazgos solamente en los accesos venosos perifericos. En los accesos centrales se observó localización, fijación,estado general de la vía, tiempo de permanencia y presencia de fiebre. Resultados: de los 3156 pacientes observados se verifico que en el 93.80% de los acceso vasculares no presentaron signos relacionados con complicaciones, se constataron modificaciones en un 6.20% de las cuales las principales fueron en las vías perifericas y segun el score de flebitis fue nivel de uno y dos la mayoria de los registros.Fue apreciable como positivo el trabajo de patrullaje, ya que logra el objetivo de detectar las posibles complicaciones y realizar los reportes de las distintas modificaciones encontradas en los accesos vasculares observados, para evaluar las acciones a seguir...


Assuntos
Humanos , Qualidade da Assistência à Saúde , Cateterismo Periférico/enfermagem , Cateterismo Venoso Central/enfermagem , Flebite
18.
Notas enferm. (Córdoba) ; 10(16): 9-12, dic. 2010.
Artigo em Espanhol | LILACS, BDENF - Enfermagem | ID: lil-595304

RESUMO

La sistematizacion de los informes de enfermeria tienen como proposito facilitar, promover, ayudar y organizar la continuidad del cuidado a la vez que permiten prevenir riesgos propios y atienden acciones en beneficio de la seguridad de los pacientes. Al finalizar cada jornada de trabajo el enfermero/a debe comunicar en forma oral al enfermero del turno entrante toda la informacion relativa a los pacientes y al servicio ocurridos en el periodo en que estuvo a cargo.


Assuntos
Humanos , Cuidados de Enfermagem , Comunicação , Registros de Enfermagem/normas , Relações Interprofissionais
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